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As part of the Integrate-LMedC project, we aim to guide and support the development of a next generation research infrastructure to facilitate the efficient use and harmonisation of large medical cohorts. In this project, we have established a working definition of what constitutes a large medical cohort. So, a medical cohort refers to a group of individuals with a shared condition, characteristic or exposure.

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Who were followed over time to collect extensive health related data and biological materials for both current and future research. However, in this project, we do not consider interventional clinical trials or data banks based solely on health registries without specific follow up as medical cohorts. We define the medical cohort as large for clinical cohorts comprising over 1000 participants, population cohorts with over 10,000 participants, and rare disease cohorts comprising approximately over 0.521% of the total disease population in a given Country.

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In the context of endometriosis research, gathering a large medical cohort allows the collection of extensive, high quality data on symptoms, genetics, disease progression, environmental risk factors, and treatment responses. This approach can help identify subtypes of endometriosis, provide insights into long term disease progression, and most importantly, accelerate advancements in treatment options while raising greater awareness of the disease.