Lung Cancer: publication in PLoS ONE for the Medical University of Bialystok, Poland

On May 5, 2022, the results of a proteomics study conducted with the use of biospecimens biobanked at the Medical University of Bialystok, were published in PLoS ONE journal in the paper entitled “Application of two-dimensional difference gel electrophoresis to identify protein changes between center, margin, and adjacent non-tumor tissues obtained from non-small-cell lung cancer with adenocarcinoma or squamous cell carcinoma subtype” (https://doi.org/10.1371/journal.pone.0268073). The biospecimens and data to run this assay were collected in the Biobank Work Package during the MOBIT Project financed by the National Center of Research and Development. With the use of a two-dimensional difference gel electrophoresis (2D-DIGE), the tissue samples from the two most common subtypes of non-small-cell lung cancer: adenocarcinoma and squamous cell carcinoma were compared. Identified proteins differentiating the tumor center and tumor margin were linked to cancer invasion and progression, including cell migration, adhesion and invasion, cytoskeletal structure, protein folding, anaerobic metabolism, tumor angiogenesis, EMC transition, epithelial adherens junctions, and inflammatory responses. The conducted study allowed to identify proteins important for the characterization of tumor development and molecular specificity of both lung cancer subtypes. What is important, found proteins may have the potential to be used as biomarkers and targets for anticancer personalized therapy.